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[171] found that in S-adenosylhomocysteine hydrolase (SAHH)-overexpressing MSCs, SAHH facilitates the dissociation of Nrf2 from Keap1, promotes Nrf2 nuclear translocation, and activates the Nrf2 pathway, thereby upregulating HO-1 and SOD1/2 expression, reducing ROS and MDA production, restoring paracrine functions (e.g., increased VEGF and IGF-1 secretion) in diabetic BMSCs, and ameliorating oxidative stress damage

M.Pereira MenezesS.Matos LimaE.Peres GramachoK.Silva AndradeB.Macdo FerreiraM.et al

Polyunsaturated fatty acid desaturation is a mechanism for glycolytic nad+ Recycling

Precision redox: the key for antioxidant pharmacology

doi: 10.1038/cddis.2014.38 19 AdhikaryGShresthaSNaselskyWNewlandJJChenXXuWet al

There is evidence for immune selection in this region, and preliminary evidence that at least one of these changes (delH69/delV70) could improve fitness [13]